Priligy and Premature Ejaculation

Premature Ejaculation can be defined as a condition in which a man finds it difficult to control his ejaculation and ejaculates too quickly during sexual intercourse, which can cause feelings of anxiety and distress.

Published: Saturday 10 November 2018

What is Premature Ejaculation?

Premature Ejaculation can be defined as a condition in which a man finds it difficult to control his ejaculation and ejaculates too quickly during sexual intercourse, which can cause feelings of anxiety and distress. This is one of the most common male sexual disorders affecting men aged between 18-64.

Some men may sometimes experience premature ejaculation, however international guidelines define premature ejaculation as an IELT (Intravaginal ejaculation latency time) of under two minutes, a history of over 6 months of premature ejaculation and feelings of anxiety and distress as a result.

Although there is limited evidence to identify the cause of premature ejaculation, there is some evidence to suggest that men with this condition have an altered sensitivity of the serotonin receptors involved in ejaculation.

How is Premature Ejaculation Treated?

Historically, a group of medications used to treat depression that selectively target the serotonin reuptake inhibitors (SSRIs), such as Paroxetine, demonstrated the ability to delay ejaculation as a side effect and have since been used as an “off label” solution to safely and effectively treat premature ejaculation. However the dose for treating premature ejaculation is lower than that used for treating patients with depression. These SSRIs are generally well tolerated with common side effects including dry mouth, fatigue, nausea, headaches and dizziness but are slow acting as it can up to 2 week to see results on delaying ejaculation.

Priligy, the first drug specifically licensed to treat premature ejaculation, contains the active ingredient dapoxetine which is also a selective serotonin reuptake inhibitor but is shorter acting and can be used as an on demand treatment when taken 1 to 3 hours before sexual intercourse. It is also rapidly eliminated from the body, with a half life of less than one and half hours. In clinical studies, compared to at baseline, IELT time improved 2 to 3 fold after taking dapoxetine 30mg and 60mg compared to the placebo study. Patients part of the studies also noted better control of ejaculation and were overall more satisfied with sexual performance than those part of the placebo.

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