Mounjaro currently shows greater average weight loss in clinical trials in the UK. It remains the most effective licensed option compared to Wegovy.
However, Wegovy is still highly effective. At the maximum licensed dose of 2.4 mg, clinical studies show that individuals who used Wegovy can lose up to 17% of their body weight within 68 weeks. This is significantly more than most people achieve with other non-injectable weight loss medications or through lifestyle changes alone.
A higher-strength dose of Wegovy (7.2mg) will become available toward the end of 2025. In clinical trials, patients lost an average of 21% of their starting body weight, with about one-third losing 25% of their starting weight or more. Side effects of this stronger dose were similar to the existing 2.4mg dose.
Furthermore, compared to Mounjaro, Wegovy is approved in the UK for reducing the risk of heart disease, does not affect oral contraceptive efficacy, and is available at a lower cost than Mounjaro.