Nytol One-A-Night 50mg Tablets

Buy Nytol One-A-Night Sleep Tablets To Help Treat Sleeplessness

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Nytol One-A-Night is an effective sleep aid for treating temporary sleeplessness, helping you get to sleep more easily and leaving you feeling well-rested.

Pack Size: 20 tablets

What is Nytol One-A-Night?

Nytol One-A-Night is an over-the-counter sleeping medication containing the active ingredient diphenhydramine hydrochloride. For those experiencing sleeping difficulties, Nytol One-A-Night acts as a sleep aid to help get a better night’s rest.

What is Nytol One-A-Night used for?

Nytol One-A-Night can be taken to help relieve temporary sleeping difficulties, which is defined as any period of sleeplessness lasting up to two weeks. Sleeping difficulties may be experienced due to a range of underlying causes such as stress, jet lag, or the side effects of medication.

How does Nytol One-A-Night work?

Nytol One-A-Night works by decreasing the level of arousal that occurs in the brain to help induce sleep more easily. Nytol contains the active ingredient diphenhydramine hydrochloride, an antihistamine that helps to block histamine from stimulating arousal-promoting areas of the brain. Nytol can be taken to help those experiencing temporary sleeplessness by making it easier to fall asleep as well as promoting more restful sleep.

Who should not take Nytol One-A-Night?

Do not take Nytol One-A-Night if you:

  • Have ever had an allergic reaction to diphenhydramine hydrochloride or any of the other ingredients within Nytol One-A-Night.
  • Have an obstruction in your stomach or gut (e.g. an ulcer).

Speak to your doctor before taking Nytol One-A-Night if you:

  • Have asthma, bronchitis or Chronic Obstructive Pulmonary Disease (COPD).
  • Have narrow-angle glaucoma (a form of raised pressure in the eye).
  • Have an enlarged prostate or experience urinary retention.
  • Have moderate to severe liver or kidney disease.
  • Have myasthenia gravis, epilepsy or seizure disorders.
  • Have an intolerance to certain sugars.
  • Have diabetes (Type 1 or Type 2).
  • Are taking any prescribed medications, particularly tricyclic antidepressants, or have taken monoamine oxidase inhibitors (MAOIs prescribed for depression) within the last two weeks, atropine (used to dilate the pupils of the eyes) or other medications that may induce drowsiness.

You should also be aware before taking Nytol One-A-Night that:

  • You should not drive or operate machinery after taking a dose.
  • You should not drink alcohol while taking a dose as this increases the effects of Nytol One-A-Night.

What’s the difference between Nytol One-A-Night, Nytol Original and Nytol Herbal Simply Sleep?

Nytol Original and Nytol One-A-Night both contain the same active ingredient, diphenhydramine, but in different doses. Nytol Original contains 25mg of diphenhydramine, whereas Nytol One-A-Night contains 50mg. Nytol Herbal Simply Sleep does not contain any diphenhydramine and instead has valerian root extract which is commonly used to treat sleep disorders, anxiety and psychological stress.

How long does Nytol One-A-Night last for?

Usually the effects of Nytol One-A-Night last between four and six hours after taking a dose. It is often reported that users feel some level of drowsiness the day after taking a dose; if this applies to you, avoid driving and operating heavy machinery.

How do you take Nytol One-A-Night?

For adults and children over 16 years old, swallow one Nytol tablet with water around 30 minutes before bed.

How do you store Nytol One-A-Night?

Store Nytol One-A-Night in a cool, dry place out of reach and sight of children. Discontinue use of Nytol after the expiry date marked on the packaging.

Can I take Nytol One-A-Night whilst pregnant or breastfeeding?

Talk to your doctor or pharmacist before taking a dose of Nytol One-A-Night if you are pregnant or breastfeeding.

How long does it take Nytol One-A-Night to work?

You should begin to feel the effects of Nytol around 20-30 minutes after taking your dose. As such, it’s recommended that you take your Nytol dose around 30 minutes before going to bed.

What are the ingredients of Nytol One-A-Night?

Nytol One-A-Night contains:

  • 50mg diphenhydramine
  • Anhydrous lactose
  • Microcrystalline cellulose
  • Maize starch
  • Stearic acid
  • Silicon dioxide

What if I forget to take a dose of Nytol One-A-Night?

If you miss a dose of Nytol One-A-Night, do not attempt to make this up the following evening by taking two. Simply continue taking the recommended dose of Nytol as instructed.

Can I take other antihistamines whilst taking Nytol One-A-Night?

Do not take other antihistamines with Nytol One-A-Night.

Written and reviewed by our qualified team

GPhC Number: 2088658

Carolina Goncalves

Authored by:

Carolina Goncalves


GPhC Number: 2225869

Rehma Gill

Reviewed by:

Rehma Gill


Find out more about how we ensure the accuracy of our content with our content guidelines.

Content last updated: 23 May 2023

Nytol One-A-Night Reviews

9.8/ 10
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Based on 266 independent customer reviews taken by Feefo (see all Feefo Reviews), Google and Trustpilot (see all Trustpilot Reviews).

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Product Review:

"Helps me sleep "

"very efficient"

Product Review:

"Exactly what i was needing"

Service Review:

"Fast delivery"

(read on Feefo)

Product Review:

"Could not buy this locally"

Service Review:

"Fast service"

(read on Feefo)

Product Review:

"The best online pharmacy x"

Service Review:

"The best quick delivery always on time have everything you neec"

(read on Feefo)

Product Review:

"Delivery very promptand price."

Service Review:

"Prompt delivery ,competitive price."

"Great service"

Product Review:

"Great product "

Service Review:

"Great service. Excellent communication and fast delivery A++"

"Have used this company before and have…"

Product Review:

"Excellent product always works and I get a great nights sleep. "

Service Review:

"Have used this company before and have always had an excellent service would recommend to anyone."

"Good price"

Product Review:

"Helps me when I’m on a 12.5 hr night shift, ensures better sleep throughout the day, "

Service Review:

"Good price, excellent communication, fast delivery."

(read on Feefo)
"Excellent service"

Product Review:

"Really helped me sleep, good product."

Service Review:

"Excellent service, quick delivery, would totally recommend this company"

(read on Feefo)

Product Review:

"I.had a good nights sleep."

Service Review:

"Fast service, really happy"

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